Overview
Bruker’s MALDI‑2 mass spectrometer provides a platform that enables data acquisition
in both electrospray and matrix‑assisted laser desorption/ionization (MALDI) modes.
Samples ranging from biological tissues to purified molecules can be analyzed on
this instrument.
Description
![MALDI-2 Mass Spectrometer](https://glycomip.org/wp-content/uploads/2021/02/MALDI_Jan-2021.jpg")
Matrix‑assisted laser desorption/ionization mass spectrometry imaging (MALDI‑MSI) is used to study the spatial distribution of molecules in sections of material, both biological and synthetic. The MALDI‑2 incorporates a second laser that increases ion yield at small pixel sizes and reduces ion suppression effects, enabling the detection of a greater number of molecular features.
The combination of MALDI‑2 with ion mobility separation (IMS) capabilities supports a wide range of applications, from the analysis of small molecules on arrays to the characterization of glycans in human tissue samples.
Applications
- Ion mobility studies
- Characterization of purified glycans and glycoproteins
- Microbial fingerprinting
- Tissue characterization
Associated Equipment:
HTX Technologies TM‑Sprayer (M3) with KNF diaphragm pump for automated and uniform application of MALDI matrix.
Instrument Status:
Available
User Access:
The MALDI‑2 is a GlycoMIP‑supported resource and is freely available to approved users of the GlycoMIP user facility.
Collaborating Laboratories:
Maintained, in part, with resources provided by the Fralin Life Sciences Institute and the Virginia Tech Mass Spectrometry Incubator.
For access to this equipment and other GlycoMIP services, please visit the User Portal.